| Description | SB-423557 is an orally active antagonist of calcium-sensing receptor (CaR) with IC50 of 520 nM |
| In vivo | SB-423557 elicits transient increases in plasma concentrations of PTH, resulting in increased bone mass and strength in both vertebrae and long bones compared to that of OVX controls. |
| Target activity | CaSR:520 nM |
| molecular weight | 464.6 |
| Molecular formula | C28H36N2O4 |
| CAS | 351490-26-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Kumar S, et al. An orally active calcium-sensing receptor antagonist that transiently increases plasma concentrations of PTH and stimulates bone formation. Bone. 2010 Feb;46(2):534-42. |