| Description | 2',3'-cGAMP (2'-3'-cyclic GMP-AMP) is a second messenger in cellular innate immunity and is catalyzed by cGAMP synthase (cGAS) under DNA binding conditions. 2',3'-cGAMP binds to STING to form a dimer, inducing the production and expression of interferon-β and other cytokines. |
| Synonyms | 2'-3'-cyclic GMP-AMP |
| molecular weight | 674.417 |
| Molecular formula | C20H24N10O13P2 |
| CAS | 1441190-66-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Zhang X, et al. Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING. Mol Cell. 2013 Jul 25;51(2):226-35. |
| Citations | 1. Zhang C, Han J, Hu S, et al.Discovery of podofilox as a potent cGAMP–STING signaling enhancer with antitumor activity.Cancer Immunology Research.2023: CIR-22-0483. |