| Description | CALP3 TFA is a potent Ca2+ channel blocker that activates EF-hand motifs of Ca2+-binding proteins. It can functionally mimic increased [Ca2+]i by modulating the activity of Calmodulin, Ca2+ channels, and pumps. |
| In vitro | CALP3 TFA (50, 100, 150, 200 μM) inhibits glutamate caused a large sustained increase in [Ca2+]i in a dose-dependent manner (IC50: 37.25 μM) in Fura-2-loaded neuronal cultures. CALP3 TFA (50, 100, 150, 200 μM) inhibits glutamate-induced cytotoxicity in a dose-dependent manner (IC50: 50.97 μM) in cultured rat neocortical neurons. CALP3 TFA causes dose-dependent inhibition of apoptosis (IC50: 33.41 μM). CALP3 TFA (100 μM) inhibits apoptosis induced by HIV gp120 and SAg in Human T cells [1]. CALP3 TFA (100?μM; 15?min pretreatment) reduces gossypol-induced necrosis and increases the fraction of live cells [2]. |
| Synonyms | CALP3 TFA |
| molecular weight | 995.1 |
| Molecular formula | C46H69F3N10O11 |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Manion MK, et al. A new type of Ca(2+) channel blocker that targets Ca(2+) sensors and prevents Ca(2+)-mediated apoptosis. FASEB J. 2000 Jul;14(10):1297-306. 2. Ferdek PE, et al. BH3 mimetic-elicited Ca2+ signals in pancreatic acinar cells are dependent on Bax and can be reduced by Ca |