| Description | (S)-3,4-DCPG HCl ((S)-3,4-Dicarboxyphenylglycine HCl) is a selective metabotropic glutamate receptor 8a (mGluR8a) agonist that has an effect on human mGluR8-expressing AV12-664 cells with an EC50 of 31 nM. |
| In vivo | (S)-3,4-DCPG（3-100 mg/kg，i.p.）在系统给药2小时后，作为特定脑区神经元活动的指标，显著增加了c-Fos的表达。在野生型小鼠中，(S)-3,4-DCPG（100 mg/kg）显著提高了几个与应激相关脑区的c-Fos表达，包括下丘脑室旁核、杏仁体中央核、外侧延脑桥脑核以及蓝斑。[2] |
| Target activity | mGluR8a (human):31 nM (EC50) |
| Synonyms | (S)-3,4-Dicarboxyphenylglycine HCl, (S)-3,4-DCPG HCl(201730-11-2 Free base) |
| molecular weight | 275.64 |
| Molecular formula | C10H10ClNO6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 10 mg/mL (36.28 mM) |
| References | 1. Thomas NK, et al. (S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist, activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord. Neuropharmacology. 2001 ; 40(3):311-318. 2. Linden AM, et al. Systemic administration of the potent mGlu8 receptor agonist (S)-3,4-DCPG induces c-Fos in stress-related brain regions in wild-type, but not mGlu8 receptor knockout mice. Neuropharmacology. 2003 ; 45(4):473-483. 3. Jiang FL, et al. Anticonvulsive effect of a selective mGluR8 agonist (S)-3,4-dicarboxyphenylglycine (S-3,4-DCPG) in the mouse pilocarpine model of status epilepticus. Epilepsia. 2007 ; 48(4):783-792. 4. Marabese I, et al. Effects of (S)-3,4-DCPG, an mGlu8 receptor agonist, on inflammatory and neuropathic pain in mice. Neuropharmacology. 2007 ; 52(2):253-262. 5. Stachowicz K, et al. Lack of the antianxiety-like effect of (S)-3,4-DCPG, an mGlu8 receptor agonist, after central administration in rats. Pharmacol Rep. 2005 ; 57(6):856-860. 6. Johnson KA, et al. The metabotropic glutamate receptor 8 agonist (S)-3,4-DCPG reverses motor deficits in prolonged but not acute models of Parkinson's disease. Neuropharmacology. 2013 ; 66:187-195. |