| Description | 3-MATIDA is an effective mGluR-1 antagonist (IC50: 6.3 μM, rat mGluR-1a). Displays ≥ 40-fold selectivity over other receptors: mGluR-5, mGluR-2, mGluR-4 (mGluR-4a) (IC50 > 300 μM), NMDA and GluR (AMPA) (IC50 = 250 μM). 3-MATIDA act as a neuroprotectant in cultured murine cortical cells and rat hippocampal slice cultures in vitro. |
| Target activity | mGluR1:6.3 μM, mGluR5:> 300 μM, GluR(AMPA):250 μM, mGluR4:> 300 μM, mGluR2:> 300 μM, NMDA:250 μM |
| molecular weight | 215.23 |
| Molecular formula | C8H9NO4S |
| CAS | 518357-51-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 2.15 mg/mL (10 mM), Sonication is recommended. 1eq. NaOH: 50 mM |
| References | 1. Moroni, F., et al.The novel and systemically active metabotropic glutamate 1 (mGlu1) receptor antagonist 3-MATIDA reduces post-ischemic neuronal death.Neuropharmacology. 2002. Neuropharmacology. 42: 741-751. 2. Cozzi, A., et al. 2002. Neuropharmacology. 43: 119-130. |