| Description | ML337 is a negative allosteric modulator of mGlu3 with an IC50 of 593 nM. |
| Target activity | mGluR3:593 nM (IC50) |
| Synonyms | ML 337 |
| molecular weight | 353.39 |
| Molecular formula | C21H20FNO3 |
| CAS | 1443118-44-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 31.8 mg/mL (90 mM) Ethanol: < 7.07 mg/mL |
| References | 1. Wenthur CJ, et, al. Discovery of (R)-(2-fluoro-4-((-4-methoxyphenyl)ethynyl)phenyl) (3-hydroxypiperidin-1-yl)methanone (ML337), an mGlu3 selective and CNS penetrant negative allosteric modulator (NAM). J Med Chem. 2013 Jun 27; 56(12): 5208-12. |