| Description | Ro 25-6981 Maleate is a selective NR2B subunit-specific NMDA receptor antagonist with anticonvulsant and antidepressant activity, which can be used in the study of neurological disorders such as Parkinson's and epilepsy. |
| In vivo | 在 6-OHDA 损伤的大鼠中，Ro 25-6981 Maleate（0.39-12.5 mg/kg；腹腔注射）能够剂量依赖性地诱导对侧的紧密鼻尾旋转，并诱发弱的同侧环绕反应，表明该化合物具有轻微的非特异性刺激作用[1]。 |
| Synonyms | Ro-25-6981 Maleate, Ro 256981 Maleate |
| molecular weight | 455.54 |
| Molecular formula | C26H33NO6 |
| CAS | 1312991-76-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: 4 mg/mL (8.78 mM), Sonication is recommended. DMSO: 61 mg/mL (133.91 mM), Sonication is recommended. |
| References | 1. Löschmann PA, et al. Antiparkinsonian activity of Ro 25-6981, a NR2B subunit specific NMDA receptor antagonist, in animal models of Parkinson's disease. Exp Neurol. 2004 May;187(1):86-93. 2. Szczurowska E,et al. Different action of a specific NR2B/NMDA antagonist Ro 25-6981 on cortical evoked potentials and epileptic afterdischarges in immature rats. Brain Res Bull. 2015 Feb;111:1-8. 3. Jiang M, et al. Antinociception and prevention of hyperalgesia by intrathecal administration of Ro 25-6981, a highly selective antagonist of the 2B subunit of N-methyl-D-aspartate receptor. Pharmacol Biochem Behav. 2013 Nov;112:56-63. |