| Description | Pregnenolone monosulfate (3β-Hydroxy-5-pregnen-20-one monosulfate) is a potent nootropic steroid that positively regulates NMDA recordings, and can be used in studies of neuroticism and depression. |
| In vitro | Pregnenolone monosulfate 作为一种信号特异性的负变构调节剂，能对大多数已知的 THC 的行为和体内效应产生拮抗作用。当切片预先用100 nM 的 Pregnenolone monosulfate 处理时，THC 的效应显著减弱（抑制率为15.1±1.8%）。 |
| Synonyms | 3β-Hydroxy-5-pregnen-20-one monosulfate |
| molecular weight | 396.54 |
| Molecular formula | C21H32O5S |
| CAS | 1247-64-9 |
| Storage | store at low temperature,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 50 mg/mL (126.09 mM), Sonication is recommended. |
| References | 1. Vallée M, et al. Pregnenolone can protect the brain from cannabis intoxication. Science. 2014 Jan 3;343(6166):94-8. 2. Ducharme N, et al. Brain distribution and behavioral effects of progesterone and pregnenolone after intranasal or intravenous administration. Eur J Pharmacol. 2010 Sep 1;641(2-3):128-34. 3. Alan Shiels. TRPM3_miR-204: a complex locus for eye development and disease. Hum Genomics. 2020 Feb 18;14(1):7. |