| Description | DL-AP5 is the racemic form of a selective N-methyl-D-aspartate (NMDA) receptor antagonist with anticonvulsant effects. |
| In vivo | DL-AP5，一种竞争性NMDAR拮抗剂，对曲马多状态依赖性记忆的研究。使用单次试验踏台下降被动避免任务评估成年雄性NMRI小鼠的记忆提取。训练后腹腔(i.p.)注射非典型μ-阿片受体激动剂曲马多（2.5和5 mg/kg），剂量依赖性地损害记忆保持。测试前注射曲马多（2.5和5 mg/kg）引起的状态依赖性记忆提取，是在训练后曲马多（5 mg/kg）影响下获得的。测试前在CA1区内注射NMDA（10^-5和10^-4 μg/鼠）距曲马多（5 mg/kg, i.p.）给药5分钟前，剂量依赖性地抑制曲马多状态依赖性记忆。测试前在CA1区内注射DL-AP5（0.25和0.5 μg/鼠）逆转了训练后曲马多（5 mg/kg）引起的记忆损害。测试前给予DL-AP5（0.25和0.5 μg/鼠）与一剂无效剂量的曲马多（1.25 mg/kg）并诱发了曲马多状态依赖性记忆。可以得出结论，背部海马NMDAR机制在调节曲马多状态依赖性记忆中起着重要作用。 |
| Synonyms | DL-2-氨基-5-膦酰基缬草酸 |
| molecular weight | 197.13 |
| Molecular formula | C5H12NO5P |
| CAS | 76326-31-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: 10 mM DMSO: Insoluble |
| References | 1. Jafari-Sabet M , Mofidi H , Attarian-Khosroshahi M S . NMDA receptors in the dorsal hippocampal area are involved in tramadol state-dependent memory of passive avoidance learning in mice[J]. Canadian Journal of Physiology and Pharmacology, 2017:cjpp-2017-0228. |