| Description | Praeruptorin A ((+)-Praeruptorin A) has the potential to inhibit migration/fusion of preosteoclasts in vitro and bone erosion in vivo by targeting calmodulin and inhibiting the Ca(2+)/calmodulin-CaMKIV-CREB-NFATc1 and/or Ca(2+)/calmodulin-calcineurin-NFATc1 signaling axis. |
| Synonyms | (+)-Praeruptorin A, 白花前胡甲素 |
| molecular weight | 386.4 |
| Molecular formula | C21H22O7 |
| CAS | 73069-27-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 45 mg/mL (116.46 mM) |
| References | 1. Xu Z1, Wang X, Dai Y, Kong L, et al.(+/-)-Praeruptorin A enantiomers exert distinct relaxant effects on isolated rat aorta rings dependent on endothelium and nitric oxide synthesis.Chem Biol Interact. 2010 Jul 30;186(2):239-46. |