| Description | Nelfinavir (AG1341) is an antiretroviral drug used in the treatment of the human immunodeficiency virus (HIV) (Ki=2 nM). Nelfinavir is a broad-spectrum, anticancer agent. |
| In vitro | Nelfinavir decreased the viability of a panel of drug-resistant breast cancer cell lines and inhibited the growth of NSCLC xenografts that was associated with induction of ER stress, autophagy, and apoptosis. Nelfinavir is a lead HIV protease inhibitor with pleiotropic effects in cancer cells[1] |
| Target activity | HIV:2 nM (ki) |
| Synonyms | AG1341, 甲磺酸萘非那韦 |
| molecular weight | 567.78 |
| Molecular formula | C32H45N3O4S |
| CAS | 159989-64-7 |
| Storage | store at low temperature|Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 100 mg/mL (176.12 mM) |
| References | 1. Gills J . Nelfinavir, a lead HIV protease inhibitor, is a broad-spectrum, anticancer agent that induces endoplasmic reticulum stress, autophagy, and apoptosis in vitro and in vivo[J]. Clin Cancer Res, 2007, 13(17):5183. 2. Mondal D , Liu K , Hamblin M , et al. Nelfinavir Suppresses Insulin Signaling and Nitric Oxide Production by Human Aortic Endothelial Cells: Protective Effects of Thiazolidinediones[J]. ochsner journal, 2013, 13(1):76. |
| Citations | 1. Liu Y, Ouyang L, Jiang S, et al.PPP2R1A silencing suppresses LUAD progression by sensitizing cells to nelfinavir-induced apoptosis and pyroptosis.Cancer Cell International.2024, 24(1): 1-13. |