| Description | NKY80 regulates the adenylyl cyclase catalytic activity in heart and lung tissues. NKY80 is a non-competitive inhibitor of adenylyl cyclase type V isoform (IC50s: 8.3 µM, 132 µM, and 1.7 mM for type V, III and II, respectively). |
| In vitro | NKY80 (20 μM) 阻断了LVP和心室cAMP水平的增加[2]。NKY80（20 μM；2小时）完全阻断了孤立的JG细胞中cAMP含量和肾素释放的升高[3]。 |
| Target activity | AC type III:132 μM, AC type V:8.3 μM, AC type II:1.7 mM |
| Synonyms | Adenylyl cyclase type V Inhibitor |
| molecular weight | 229.23 |
| Molecular formula | C12H11N3O2 |
| CAS | 299442-43-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 225 mg/mL (981.5 mM), Sonication is recommended. |
| References | 1. Onda T, et al. Type-specific regulation of adenylyl cyclase. Selective pharmacological stimulation and inhibitionof adenylyl cyclase isoforms. Biol Chem. 2001 Dec 21;276(51):47785-93. 2. Harney JA, et al. Insulin-like stimulation of cardiac fuel metabolism by physiological levels of glucagon: involvement of PI3K but not cAMP. Am J Physiol Endocrinol Metab. 2008 Jul;295(1):E155-61. 3. Ortiz-Capisano MC, et al. Adenylyl cyclase isoform v mediates renin release from juxtaglomerular cells. Hypertension. 2007 Mar;49(3):618-24. |