| Description | AC1-IN-1 is a selective inhibitor of adenylyl cyclase type 1 (AC1, IC50 = 0.54 µM). |
| In vitro | 在HEK293细胞中，AC1-IN-1（30 µM，1小时）对这一人类细胞系表现出无毒性【1】。 |
| In vivo | AC1-IN-1 (5.6 mg/kg; i.v.) 在治疗后1小时与治疗前0分钟相比展示了适度但有统计学意义的抗痛觉过敏效果[1]。 |
| molecular weight | 355.37 |
| Molecular formula | C18H18FN5O2 |
| CAS | 2762422-55-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 11 mg/mL (30.95 mM) |
| References | 1. Scott JA, et al. Optimization of a Pyrimidinone Series for Selective Inhibition of Ca2+/Calmodulin-Stimulated Adenylyl Cyclase 1 Activity for the Treatment of Chronic Pain. J Med Chem. 2022; 65(6):4667-4686. |