| Description | NKH477 is a novel water-soluble forskolin derivative that improves cardiac failure mainly through its beneficial effects on diastolic cardiac function. NKH477 shows an antiproliferative effect in vivo with an altered cytokine profile to inhibit the acute rejection of rat orthotopic lung allografts. NKH477 directly activates the catalytic unit of adenylate cyclase and enhances intracellular cAMP . |
| In vivo | NKH477 (p.o.; 1-3 mg/kg/day; days 3 and 5) prolonged lung allograft survival in a dose dependent manner. |
| Synonyms | Colforsin dapropate hydrochloride |
| molecular weight | 546.09 |
| Molecular formula | C27H44ClNO8 |
| CAS | 138605-00-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Nakashima S, et al. Antiproliferative effects of NKH477, a forskolin derivative, on cytokine profile in rat lung allografts. J Heart Lung Transplant. 2005 Apr;24(4):462-9. |
| Citations | 1. Liu C, Sun W, Zhu T, et al. Glia maturation factor-β induces ferroptosis by impairing chaperone-mediated autophagic degradation of ACSL4 in early diabetic retinopathy. Redox Biology. 2022: 102292. |