| Description | Ro 8-4304 Hydrochloride is an antagonist of NMDA receptor with IC50 of 0.4 μM |
| In vitro | Ro 8-4304 是一种对大鼠培养皮层神经元中NMDA受体的电压独立的、非竞争性拮抗剂，其作用方式呈现出依赖状态。Ro 8-4304对NMDA受体的表观亲和力随NMDA浓度的增加而提高，因此Ro 8-4304以IC50分别为2.3和0.36μM，抑制了10和100μMNMDA反应。在10μMRo 8-4304的存在下，由1μMNMDA引起的电流略有增强，并且Ro 8-4304的结合减缓了谷氨酸从NMDA受体解离的速率。 |
| Target activity | NMDA:0.4 μM |
| Synonyms | Ro 8-4304 Hydrochloride |
| molecular weight | 370.42 |
| Molecular formula | C21H23FN2O3 |
| CAS | 195988-65-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Kew J N C , Trube G , Kemp J A . State-dependent NMDA receptor antagonism by Ro 8-4304, a novel NR2B selective, non-competitive, voltage-independent antagonist[J]. British Journal of Pharmacology, 1998, 123(3):463-472. 2. Huang S , Balgi A , Pan Y , et al. Identification of Methylosome Components as Negative Regulators of Plant Immunity Using Chemical Genetics[J]. 2016, 009(012):1620-1633. |