| Description | GV-196771A A novel NMDA receptor glycine site antagonist with potent antinociceptive activity. |
| In vivo | GV196771A是一种专为治疗神经病性疼痛而开发的强效拮抗剂，其作用靶点是N-甲基-D-天冬氨酸受体(NMDA受体)的调节性甘氨酸位点。GV196771A在大鼠和小鼠中显示出低的口服生物利用度，生物利用度不足10%，并且血浆清除率约为2 mL/min/kg[1]。 |
| molecular weight | 423.23 |
| Molecular formula | C20H13Cl2N2NaO3 |
| CAS | 166974-23-8 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Polli JW, et al. The systemic exposure of an N-methyl-D-aspartate receptor antagonist is limited in mice by the P-glycoprotein and breast cancer resistance protein efflux transporters. Drug Metab Dispos. 2004 Jul;32(7):722-6. |