| Description | ND-322 HCl (ND 322 Hydrochloride) is a selective inhibitor of MT1-MMP and MMP2 and reduces in vitro melanoma cell growth, migration and invasion. |
| Synonyms | ND 322 Hydrochloride, ND322 Hydrochloride, ND-322 Hydrochloride, ND322 HCl |
| molecular weight | 357.88 |
| Molecular formula | C15H16ClNO3S2 |
| CAS | 1333379-23-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 45 mg/mL (125.74 mM) |
| References | 1. Meisel JE, Chang M. Selective small-molecule inhibitors as chemical tools to define the roles of matrix metalloproteinases in disease. Biochim Biophys Acta. 2017 Nov;1864(11 Pt A):2001-2014. 2. Marusak C, et al. The thiirane-based selective MT1-MMP/MMP2 inhibitor ND-322 reduces melanoma tumor growth and delays metastatic dissemination. Pharmacol Res. 2016 Nov;113(Pt A):515-520. 3. Yan Y, et al. Synthesis of chiral ND-322, ND-364 and ND-364 derivatives as selective inhibitors of human gelatinase. Bioorg Med Chem. 2015 Oct 15;23(20):6632-40. 4. Song W, et al. Water-soluble mmp-9 inhibitor prodrug generates active metabolites that cross the blood-brain barrier. ACS Chem Neurosci. 2013 Aug 21;4(8):1168-73. |