| Description | Batimastat (BB94) (BB-94) is an effective, broad-spectrum matrix metalloprotease (MMP) inhibitor. Batimastat induces extracellular matrix degradation and inhibits angiogenesis, tumor growth and invasion, and metastasis. |
| In vitro | Batimastat (BB-94) 是一种强效的、广谱的基质金属蛋白酶(MMP)抑制剂，针对MMP-1, MMP-2, MMP-9, MMP-7和MMP-3，其IC50分别为3 nM, 4 nM, 4 nM, 6 nM和20 nM。Batimastat展现出意外的结合几何形态，其中噻吩环深入主要特异性位点。 |
| In vivo | Batimastat能抑制B16-BL6小鼠黑色素瘤的转移扩散和生长。[1] 在小鼠的原位结肠肿瘤模型中，timastat的治疗能够抑制主要肿瘤生长(50%)、局部/区域性扩散(从67%降至35%)及远处转移(从30%降至10%)。[3]Batimastat通过阻断变异细胞招募内皮细胞或干扰血管结构中的细胞组织，最有可能减缓实验性血管瘤的体内生长。[4] |
| Target activity | MMP1:3 nM, MMP7:6 nM, MMP2:4 nM, MMP9:4 nM, MMP3:20 nM |
| Synonyms | 巴马司他, BB94 |
| molecular weight | 477.64 |
| Molecular formula | C23H31N3O4S2 |
| CAS | 130370-60-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 47.8 mg/mL (100 mM) |
| References | 1. Chirivi RG, et al. Int J Cancer, 1994, 58(3), 460-464. 2. Botos I, et al. PNAS, 1996, 93(7), 2749-2754. 3. Wang X, et al. Cancer Res, 1994, 54(17), 4726-4728. 4. Taraboletti G, et al. J Natl Cancer Inst, 1995, 87(4), 293-298. 5. Liu Y, Wei H, Tang J, et al. Dysfunction of pulmonary epithelial tight junction induced by silicon dioxide nanoparticles via the ROS/ERK pathway and protein degradation[J]. Chemosphere. 2020, 255: 126954. |
| Citations | 1. Liu Y, Wei H, Tang J, et al. Dysfunction of pulmonary epithelial tight junction induced by silicon dioxide nanoparticles via the ROS/ERK pathway and protein degradation. Chemosphere. 2020, 255: 126954. 2. Qiu L, Xu H, Sui B, et al.Elucidating the Functional Mechanism of PTK7 in Cancer Development through Spatial Assembly Analysis Using Super Resolution Imaging.Analytical Chemistry.2024 |