| Description | MTEP hydrochloride (MTEP) is non-competitive mGlu5 antagonist (IC50 and Ki of 5 nM and 16 nM, respectively) |
| In vivo | 使用雄性瑞士白鼠进行实验，通过FST方法评估抗抑郁样活性。MTEP (0.3 mg/kg) 的抗抑郁样效应被NMDA受体激动剂N-甲基-D-天门冬氨酸（NMDA, 75 mg/kg）预处理显著对抗[1]。 |
| Target activity | mGlu5:16 nM(ki), mGlu5:5 nM |
| Synonyms | 3-((2-Methyl-1,3-thiazol-4-yl)ethyn-yl)pyridine hydrochloride, 3-[2-(2-甲基-4-噻唑基)乙炔基]吡啶盐酸盐, MTEP |
| molecular weight | 236.72 |
| Molecular formula | C11H9ClN2S |
| CAS | 1186195-60-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: 20 mg/mL (84.49 mM), Sonication is recommended. |
| References | 1. NMDA but not AMPA glutamatergic receptors are involved in the antidepressant-like activity of MTEP during the forced swim test in mice[J]. Pharmacological Reports, 2010, 62(6):1186-1190. 2. Neuroprotective potential of mGluR5 antagonist MTEP: effects on kainate-induced excitotoxicity in the rat hippocampus[J]. Pharmacological Reports, 2010, 62(6):1051-1061. |