| Description | Chelidamic acid is a heterocyclic organic acid with a pyran skeleton. Chelidamic acid is inhibitors of glutamate decarboxylase, with a Ki of 33 μM. |
| In vitro | Chelidamic acid 抑制了谷氨酸依赖的脱辅酶形成。Chelidamic acid 本身不促进脱辅酶的形成，也不与游离的吡哆醛磷酸反应。Chelidamic acid 是谷氨酸脱羧酶的抑制剂，其Ki值为33 μM[1]。 |
| Target activity | Glutamate decarboxylase (GAD):33 μM (Ki) |
| Synonyms | 4-氧代-1,4-二氢-2,6-吡啶二甲酸, 白屈氨酸 |
| molecular weight | 183.12 |
| Molecular formula | C7H5NO5 |
| CAS | 138-60-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 60 mg/mL (327.65 mM), Sonication is recommended. |
| References | 1. Porter T G , Martin D L . Chelidonic acid and other conformationally restricted substrate analogues as inhibitors of rat brain glutamate decarboxylase[J]. Biochemical Pharmacology, 1986, 34(23):4145-4150. 2. Espinet P , García-Orodea, Esther, Miguel, Jesús A. Mesogenic Palladium Complexes with Pincer Ligands Derived from Dipicolinic Acid\r, ?[J]. Inorganic Chemistry, 2000, 39(16):3645-3651. |