| Description | FITM is a potent negative allosteric modulator of mGlu1 receptor(Ki : 2.5 nM). |
| Target activity | mGlu1:2.5 nM(KI) |
| Synonyms | 4-氟-N-[4-[6-(异丙基氨基)嘧啶-4-基]-1,3-噻唑-2-基]-N-甲基苯甲酰胺 |
| molecular weight | 371.43 |
| Molecular formula | C18H18FN5OS |
| CAS | 932737-65-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 150 mg/mL (403.84 mM) |
| References | 1. Hayes M , Choudhary V , Ojha N , et al. Fat storage-inducing transmembrane (FIT or FITM) proteins are related to lipid phosphatase/phosphotransferase enzymes[J]. Microbial cell (Graz, Austria), 2017, 5(2):88. 2. Wu H , Wang C , Gregory K J , et al. Structure of a Class C GPCR Metabotropic Glutamate Receptor 1 Bound to an Allosteric Modulator[J]. Science, 344. |