| Description | ML289 (VU0463597) is a potent, selective, and CNS-penetrant negative allosteric modulator of mGlu3 (IC50=0.66 μM), demonstrating over 15-fold selectivity compared to mGlu2 and showing no activity against mGlu5. |
| In vitro | ML289（VU0463597）是一种能渗透中枢神经系统(CNS)的代谢型谷氨酸受体3（mGlu3）负向异构调节剂探针[1]。 |
| Target activity | mGluR3:0.66 μM (IC50) |
| Synonyms | VU0463597, ML 289 |
| molecular weight | 349.42 |
| Molecular formula | C22H23NO3 |
| CAS | 1382481-79-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 225 mg/mL (643.9 mM), Sonication is recommended. |
| References | 1. Sheffler DJ, et al. Development of a novel, CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) NAM probe (ML289) derived from a closely related mGlu5 PAM. Bioorg Med Chem Lett. 2012;22(12):3921-3925. |