| Description | ML-098 (CID-7345532) is an activator of the GTP-binding protein Rab7 (EC50: 77.6 nM). |
| In vitro | ML098 (CID-7345532) functions by increasing the affinity of the GTPases for guanine nucleotides, leading to the hypothesis that these activators interact with GTPases bind to an allosteric binding site localized between switch regions I and II. ML-098 is an activator of the GTP-binding protein Rab7 with an EC50 of 77.6 nM which shows selectivity against the related GTPases cdc42, Ras, Rab-2A, and Rac1 (EC50s = 588.8, 346.7, 158.5, and 794.3 nM, respectively)[1]. |
| Target activity | Rab7:77.6 nM (EC50) |
| Synonyms | CID-7345532 |
| molecular weight | 309.36 |
| Molecular formula | C19H19NO3 |
| CAS | 878978-76-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 50 mg/mL (161.6 mM) |
| References | 1. Surviladze, Z., Ursu, O., Miscisocia, F., et al. UNMCMD Probe Report: Three small molecule pan activator families of Ras-related GTPases 1-42 (2009). |
| Citations | 1. Cao Z, Li P, Li Y, et al.Encapsulation of Nano‐Bortezomib in Apoptotic Stem Cell‐Derived Vesicles for the Treatment of Multiple Myeloma.Small.2023: 2301748. 2. Piper B, Bogamuwa S, Hossain T, et al.RAB7 deficiency impairs pulmonary artery endothelial function and promotes pulmonary hypertension.bioRxiv.2023: 2023.02. 03.526842. |