| Description | XE 991 dihydrochloride is a Kv7 (KCNQ) channel blocker. XE 991 dihydrochloride potently inhibits Kv7.1 (KCNQ1), Kv7.2 (KCNQ2), Kv7.2 + Kv7.3 (KCNQ3) channel, and M-current (IC50s: 0.75 μM, 0.71 μM, 0.6 μM, and 0.98 μM, respectively). |
| Target activity | M-current:0.98 μM, Kv7.2 channel:0.71 μM, Kv7.1 channel:0.75 μM, Kv7.2/Kv7.3 channel:0.6 μM |
| molecular weight | 449.37 |
| Molecular formula | C26H22Cl2N2O |
| CAS | 122955-13-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 12 mg/mL (26.7 mM) |