| Description | ML402 (ZINC3671497) is an activator of TREK-1 and TREK-2 with EC50s of 13.7 μM and 5.9 μM. |
| In vitro | ML402 targets TRAAK with EC50 of 13.6 μM[1]. |
| Synonyms | ZINC3671497, N-[2-(4-chloro-2-methylphenoxy)ethyl]thiophene-2-carboxamide |
| molecular weight | 295.78 |
| Molecular formula | C14H14ClNO2S |
| CAS | 298684-44-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 95 mg/mL (321.18 mM) |
| References | 1. Lolicato M, et al. K2P2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding site. Nature. 2017 Jul 20;547(7663):364-368. |