| Description | MKA031 (compound 6y) is a non-competitive inhibitor of macrophage migration inhibitory factor (MIF), exhibiting an IC50 of 1.7 μM. It disrupts the MIF-aryl hydrocarbon receptor interacting protein (AIF) interaction, impedes MIF nuclear translocation, and mitigates N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced cell death. MKA031 is applicable in research on chronic hepatitis C virus infection [1]. |
| In vitro | MKA031（compound 6y）（1-100 μl；3 h）有效抑制了MNNG引起的细胞凋亡，并在100 μl浓度下作用3小时，通过干扰MIF与AIF之间的相互作用，保护了基因组DNA免遭损伤[1]。 |
| molecular weight | 403.46 |
| Molecular formula | C21H17N5O2S |
| CAS | 2951012-00-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |