| Description | MS78, an acetylation targeting chimera (AceTAC), specifically acetylates the p53Y220C mutant by recruiting the histone acetyltransferase p300/CBP. This compound enhances the expression of TRAIL apoptotic genes while concurrently suppressing DNA damage response pathways. Its structure comprises a CBP/p300 binding domain, a p53Y220C targeting moiety, and a connecting linker [1]. |
| molecular weight | 1024.25 |
| Molecular formula | C57H66FN9O6S |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |