| Description | Mitoquinone mesylate (MitoQ10 mesylate) is a TPP-based, mitochondrially targeted antioxidant to protect against oxidative damage. |
| In vitro | 相较于未处理的细胞，正常大鼠肾脏（NRK）细胞在接触到CS之后，诱导线粒体超氧化物的增加，荧光强度升高。Mitoquinone明显有效地保护线粒体免受CS诱导的超氧化物生成的损害[1]。 |
| In vivo | Mitoquinone (MitoQ) 处理在10mg/kg (剂量1)[2]下显著增加了由Caerulein诱导的肺MPO活性，同时血清IL-6水平也显著升高。 |
| Synonyms | MitoQ mesylate, 米托蒽醌甲磺酸盐, MitoQ10 mesylate |
| molecular weight | 678.81 |
| Molecular formula | C38H47O7PS |
| CAS | 845959-50-4 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 50 mg/mL (73.66 mM), Sonication is recommended. H2O: < 0.1 mg/mL (insoluble) |
| References | 1. Mitchell T, et al. The mitochondria-targeted antioxidant mitoquinone protects against cold storage injury of renaltubular cells and rat kidneys. J Pharmacol Exp Ther. 2011 Mar;336(3):682-92. 2. Huang W, et al. Effects of the mitochondria-targeted antioxidant mitoquinone in murine acute pancreatitis. Mediators Inflamm. 2015;2015:901780. |
| Citations | 1. Huang X, Liang N, Zhang F, et al.Lovastatin-Induced Mitochondrial Oxidative Stress Leads to the Release of mtDNA to Promote Apoptosis by Activating cGAS-STING Pathway in Human Colorectal Cancer Cells.Antioxidants.2024, 13(6): 679. |