| Description | J-14 is an inhibitor of reversible sulfiredoxin(IC50 : 8.1 μM). J14 induces oxidative stress (intracellular ROS accumulation) by inhibiting sulfiredoxin, leading to cytotoxicity and cancer cell death |
| Target activity | Sulfiredoxin:8.1 μM |
| Synonyms | J-14 |
| molecular weight | 517.04 |
| Molecular formula | C28H25ClN4O2S |
| CAS | 1043854-13-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 260 mg/mL (502.86 mM), Sonication is recommended. |
| References | 1. Kim H, et al. Sulfiredoxin inhibitor induces preferential death of cancer cells through reactive oxygen species-mediated mitochondrial damage. Free Radic Biol Med. 2016 Feb;91:264-74. |