| Description | Methyl nicotinate (methyl pyridine-3-carboxylate) is the methyl ester of that is used as an active ingredient as a rubefacient in over-the-counter topical preparations indicated for muscle and joint pain. The action of methyl nicotinate as a rubefacient is thought to involve peripheral vasodilation. |
| In vivo | 局部使用 comfrey 根提取物和甲基尼可酸酯的组合对患有急性上部或下部背痛的患者的治疗结果有着临床上显著的积极影响。接受该组合治疗的患者在疼痛评分上有统计学意义上的显著减少，同时在触痛感上也有显著增加。 |
| Animal experiments | Patients were randomised and subsequently treated until Day 5 (fourth day after enrolment). One group of patients received a combination cream containing 35% of comfrey root extract (1:2, extractant 60 v/v%), and 1.2% methyl nicotinate (Kytta-Balsam? f, Merck Selbstmedikation GmbH, Darmstadt, Germany), the second group a cream containing 1.2% methyl nicotinate, and the third a placebo cream. Treatment was started after trial enrolment. Patients were seen for evaluation of treatment effects after 1 h and after 3 and 5 days (± 1 day) |
| Synonyms | 烟酸甲酯, methyl pyridine-3-carboxylate |
| molecular weight | 137.14 |
| Molecular formula | C7H7NO2 |
| CAS | 93-60-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 45 mg/mL (328.13 mM) |
| References | 1. Pabst H , Schaefer A , Staiger C , et al. Combination of Comfrey Root Extract Plus Methyl Nicotinate in Patients with Conditions of Acute Upper or Low Back Pain: A Multicentre Randomised Controlled Trial[J]. Phytotherapy Research, 2013, 27(6):811-817. |