(1R,2R)-2-PCCA hydrochloride Bioactivity,Chemical Properties,Storage & Solubility Information Pathways-PeptideDB

Description	(1R,2R)-2-PCCA hydrochloride is a potent, selective, and blood-brain-barrier-crossing GPR88 receptor agonist with an EC50 value of 1140 n in striatal membranes of WT mice.(1R,2R)-2-PCCA hydrochloride can be used to study the central nervous system.
In vitro	(1R,2R)-2-PCCA hydrochloride 是一种有效的GPR88受体激动剂，在无细胞实验中具有3 nM的EC50，而在细胞实验中EC50为603 nM[1]。通过Gαi耦联途径，(1R,2R)-2-PCCA hydrochloride能够抑制GPR88介导的cAMP产生，在稳定表达人GPR88受体和GloSensor-22F的HEK293细胞中的cAMP构建物中EC50为56 nM[1]。
Target activity	GPR88-22F cells:603 nM (EC50), GPR88 receptor:3 nM (EC50, cell-free assay), GPR88 receptor:56 nM (EC50, HEK293 cell)
Synonyms	(1R,2R)-2-PCCA(hydrochloride)
molecular weight	528.56
Molecular formula	C30H39Cl2N3O
CAS	1609563-71-4
Storage	store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility	DMSO: 20 mg/mL (37.84 mM), Sonication is recommended.
References	1. Jin C, et al. Effect of Substitution on the Aniline Moiety of the GPR88 Agonist 2-PCCA: Synthesis, Structure-Activity Relationships, and Molecular Modeling Studies. ACS Chem Neurosci. 2016 Oct 19;7(10):1418-1432. 2. Jin C, et al. Synthesis, pharmacological characterization, and structure-activity relationship studies of small molecular agonists for the orphan GPR88 receptor. ACS Chem Neurosci. 2014 Jul 16;5(7):576-87.

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