| Description | Helicin is a syrB inducer found in the Rosaceae family. Helicin is hydrolyzed by the enzyme BglY. |
| In vitro | 为了从Streptomyces flavoretus 18522的代谢物中寻找细胞周期抑制剂，采用了以下方法和结果：使用ts FT210细胞，通过对Streptomyces flavoretus 18522的发酵液和菌丝体的氯仿提取物进行活性导向分离。通过各种色谱方法分离化合物，并通过光谱方法进行结构解析。利用流式细胞仪评价了各分馏部分及化合物的细胞周期抑制活性。最终获得并鉴定了六种环状二肽，分别为cyclo(Ala-Leu)(1)、Cyclo(Ile-Ala) (2)、cyclo(Ala-Val)(3)、cyclo(Phe-Leu)(4)、cyclo(Ala-Pro)(5)和cyclo(Phe-Val)(6)。结论：化合物1-6首次被报告为新的细胞周期抑制剂。 |
| molecular weight | 184.24 |
| Molecular formula | C9H16N2O2 |
| CAS | 90821-99-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 5.6 mg/mL (30.4 mM) |
| References | 1. Cyclic dipeptides as new cell cycle inhibitors produced by Streptomyces flavoretus 18522 Journal of Shenyang Pharmaceutical University, 2015 (2) :107 -10. |