| Description | MC3482 is a specific inhibitor of sirtuin5 (SIRT5). |
| In vitro | MC3482能够抑制sirtuin5。50 μM MC3482可阻断SIRT5的去琥珀酰化活性，而不影响SIRT5在细胞内的表达水平。在SIRT5沉默细胞和用MC3482处理的WT细胞中，自噬和线粒体自噬水平增加，但在过表达SIRT5的细胞中则降低[1]。 |
| molecular weight | N/A |
| CAS | 2922280-86-0 |
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 117mg/mL (189.1mM) |
| References | 1. Polletta L, et al. SIRT5 regulation of ammonia-induced autophagy and mitophagy. Autophagy. 2015;11(2):253-70. |