| Description | Et-29 is a selective inhibitor of SIRT5 inhibitor with a Ki of 40 nM. |
| Target activity | SIRT5:40 nM (Ki) |
| Synonyms | NRD167 |
| molecular weight | 666.83 |
| Molecular formula | C34H46N6O6S |
| CAS | 2166487-23-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 90 mg/mL (135 mM), Sonication is recommended. |
| References | 1. Li M , Melnick A M . Non-oncogene Addiction to SIRT5 in Acute Myeloid Leukemia[J]. American Association for Cancer Research Journals, 2021(3). 2. Rajabi N, et al. Mechanism-Based Inhibitors of the Human Sirtuin 5 Deacylase: Structure-Activity Relationship, Biostructural, and Kinetic Insight. Angew Chem Int Ed Engl. 2017;56(47):14836-14841. |