| Description | SIRT6-IN-5（SIRT6 inhibitor 5） is a potent and selective SIRT6 inhibitor with an IC50 value of 34 μM.SIRT6-IN-5 is immunosuppressive and chemo-sensitizing, increases H3K9 acetylation and glucose uptake in cultured cells, and reduces T-cell proliferation. |
| Target activity | SIRT6:34 μM |
| Synonyms | SIRT6 inhibitor5, SIRT6 IN 5, SIRT6 inhibitor-5, SIRT6 inhibitor 5 |
| molecular weight | 366.32 |
| Molecular formula | C19H14N2O6 |
| CAS | 891002-11-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 55 mg/mL (150.14 mM) |
| References | 1. Damonte P, et al. SIRT6 inhibitors with salicylate-like structure show immunosuppressive and chemosensitizing effects. Bioorg Med Chem. 2017 Oct 15;25(20):5849-5858. 2. Wencel PL, et al. Inhibition of Poly(ADP-ribose) Polymerase-1 Enhances Gene Expression of Selected Sirtuins and APP Cleaving Enzymes in Amyloid Beta Cytotoxicity. Mol Neurobiol. 2017 Jul 12. 3. Shao J, et al. Autophagy induction by SIRT6 is involved in oxidative stress-induced neuronal damage. Protein Cell. 2016 Apr;7(4):281-90. 4. Kokkonen P, et al. Studying SIRT6 regulation using H3K56 based substrate and small molecules. Eur J Pharm Sci. 2014 Oct 15;63:71-6. |