| Description | MAO-B-IN-4 (Compound 26) is a reversible monoamine oxidase B (MAO-B) inhibitor with potent in vitro activity, characterized by an IC50 value of 9 nM. This orally active compound exhibits favorable metabolic stability, a satisfactory safety profile, and effective brain permeability. Demonstrating antidepressant effects in rodent models, MAO-B-IN-4 is suitable for research into Alzheimer's disease [1]. |
| In vitro | MAO-B-IN-4 以0.25 μM浓度在含0.5μM DOX的培养环境中处理星形胶质细胞模型24小时，展现了显著的神经保护效果[1]。 |
| In vivo | MAO-B-IN-4在剂量为1和3 mg/kg时，经口服给予2小时后，能够预防由东莨菪碱引起的短期记忆障碍[1]。以0.312至2.5 mg/kg剂量，通过静脉注射给予1小时后，能改善小鼠在强迫游泳试验中的抗抑郁表现[1]。 |
| molecular weight | 411.87 |
| Molecular formula | C23H20ClF2N3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |