| Description | MAO-B-IN-18 is a potent, selective inhibitor of MAO B, demonstrating IC50 values of 52 nM for hMAO B and 14 μM for hMAO A. It exhibits cytoprotective effects against hydrogen peroxide-induced damage in neuroblastoma and astrocyte cultures [1]. |
| In vitro | MAO-B-IN-18（化合物20；0.1、0.5、1、5μM）在SH-SY5Y神经母细胞瘤细胞中发挥保护作用，可通过中度ROS清除机制减轻促氧化伤害[1]。此外，MAO-B-IN-18（5μM）与过氧化氢（400μM）共孵育时，能保持DI TNC1星形胶质细胞系的活细胞数量，在槲皮素（阳性对照，75μM）高剂量作用下相当[1]。 |
| Target activity | MAO-B (human):52 nM, MAO-A (human):14 μM |
| molecular weight | 458.47 |
| Molecular formula | C25H22N4O5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |