| Description | LY382884 is a selective and potent GluR5 kainate receptor antagonist with anxiolytic activity.LY382884 blocks blockade of mossy fibre LTP induction. |
| Synonyms | LY-382884, LY 382884 |
| molecular weight | 317.38 |
| Molecular formula | C18H23NO4 |
| CAS | 211566-75-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Lauri SE,et al. Synaptic activation of a presynaptic kainate receptor facilitates AMPA receptor-mediated synaptic transmission at hippocampal mossy fibre synapses. Neuropharmacology. 2001 Dec;41(8):907-15. 2. Binns KE, Turner JP, Salt TE. Kainate receptor (GluR5)-mediated disinhibition of responses in rat ventrobasal thalamus allows a novel sensory processing mechanism. J Physiol. 2003 Sep 1;551(Pt 2):525-37. Epub 2003 Aug 8. PubMed PMID: 12909680; PubMed Central PMCID: PMC2343236. 3. Evanson NK, Van Hooren DC, Herman JP. GluR5-mediated glutamate signaling regulates hypothalamo-pituitary-adrenocortical stress responses at the paraventricular nucleus and median eminence. Psychoneuroendocrinology. 2009 Oct;34(9):1370-9. doi: 10.1016/j.psyneuen.2009.04.011. Epub 2009 May 18. PubMed PMID: 19450932; PubMed Central PMCID: PMC2763572. 4. Palecek J, Neugebauer V, Carlton SM, Iyengar S, Willis WD. The effect of a kainate GluR5 receptor antagonist on responses of spinothalamic tract neurons in a model of peripheral neuropathy in primates. Pain. 2004 Sep;111(1-2):151-61. PubMed PMID: 15327819. |