| Description | Kasugamycin hydrochloride hydrate (Ksg (hydrochloride hydrate))(Ksg) specifically inhibits translation initiation of canonical but not of leaderless messenger RNAs. Ksg inhibition is thought to occur by direct competition with initiator transfer RNA |
| Synonyms | Ksg (hydrochloride hydrate), 春雷霉素盐酸盐一水合物 |
| molecular weight | 433.84 |
| Molecular formula | C14H28ClN3O10 |
| CAS | 200132-83-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: < 1 mg/mL (insoluble）, Sonication and heating are recommended. |
| References | 1. Christian Lange , Matthias Lehr , Karolin Zerulla.Effects of Kasugamycin on the Translatome of Escherichia Coli.PLoS One. 2017 Jan 12;12(1):e0168143. 2. Schuwirth BS, et al. Structural analysis of kasugamycin inhibition of translation. Nat Struct Mol Biol. 2006 Oct;13(10):879-86. 3. Schluenzen F, et al. The antibiotic kasugamycin mimics mRNA nucleotides to destabilize tRNA binding and inhibit canonical translation initiation. Nat Struct Mol Biol. 2006 Oct;13(10):871-8. |
Kasugamycin hydrochloride hydrate
CAS No.: 200132-83-8
Kasugamycin hydrochloride hydrate (Ksg (hydrochloride hydrate))(Ksg) specifically inhibits translation initiation of can
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.