| Description | Kansuiphorin C (KPC) is a natural product with a number of bioactivity. KPC could ameliorate malignant ascites by modulating gut microbiota mainly containing the increase of Lactobacillus and the decrease of Helicobacter and related carbohydrate and amino acid metabolism. |
| In vivo | Kansuiphorin C (KPC) 是一种调节肠道菌群的化合物。Lactobacillus 的丰富度增加以及涉及碳水化合物和氨基酸代谢的 Helicobacter 的丰富度减少，可能是其对恶性腹水产生抑制效应的原因。KPC 通过将 Helicobacter 的丰度降低约3.5倍，展现出比 KA 更强的肠道菌群调节作用。此外，Kansuiphorin C (KPC) 在体内的微生物生物转化过程包括氧化、水解、脱水和甲基化，形成了极性较低的代谢产物。同时，在 10 mg kg-1 的剂量下，这两种化合物对正常大鼠肠道菌群的毒性影响较小[1]。 |
| Synonyms | KPC, 甘遂大戟萜酯C |
| molecular weight | 478.58 |
| Molecular formula | C29H34O6 |
| CAS | 133898-77-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 30 mg/ml (62.69 mM) |
| References | 1. Zhang Y , Lou J W , Kang A , et al. Kansuiphorin C and Kansuinin A ameliorate malignant ascites by modulating gut microbiota and related metabolic functions[J]. Journal of Ethnopharmacology, 2019, 249:112423.Kansuiphorin C and Kansuinin A ameliorate malignant ascites by modulating gut microbiota and related metabolic functions. 2. Concise stereocontrolled routes to fumagillol, fumagillin, and TNP-470. |