| Description | Isoastilbin is a dihydroflavonol glycoside compound in Rhizoma Smilacis glabrae and Astragalus membranaceus. Isoastilbin inhibits glucosyltransferase (GTase) with an IC50 value of 54.3 μg/mL, Isoastilbin has anti-acne and tyrosinase inhibition properties. Isoastilbin shows neuroprotective, antioxidation, antimicrobial and anti-apoptotic properties and has the potential for Alzheimer s disease research |
| In vitro | 粗提取物经抗微生物活性检测，针对Streptococcus sobrinus及葡萄糖基转移酶(GTase)抑制作用进行评估。其中十四份提取物在100 μg/ml的浓度下对S. sobrinus的生长抑制率超过50%，六份提取物对GTase的活性抑制率也超过50%。Koompassia malaccensis（kempas）提取物在相同浓度下对S. sobrinus生长的抑制率达90%，对GTase活性的抑制率达80%。通过使用Sephadex LH-20柱色谱和制备用高效液相色谱法，对kempas粗提取物进行了分离，从而分离出四种化合物A、B、C和D。通过1H和13C核磁共振（NMR）光谱及其他二维NMR技术（COSY、HMBC和HMQC），确定这些化合物分别为taxifolin及flavanonol rhamnoside异构体neoastilbin、astilbin和Isoastilbin。这些化合物在9.3242.7 μg/ml的浓度范围内均显著抑制了S. sobrinus的生长，并显示出27.4-57.3 μg/ml范围内的GTase抑制活性的IC50值[1]。 |
| Target activity | GTase:54.3 μg/mL (IC50) |
| molecular weight | 450.39 |
| Molecular formula | C21H22O11 |
| CAS | 54081-48-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 25 mg/mL (55.51 mM) |
| References | 1. Antimicrobial activity against Streptococcus sobrinus and glucosyltransferase inhibitory activity of taxifolin and some flavanonol rhamnosides from kempas (Koompassia malaccensis) extractsJ. Wood Sci., 2009, 55(4):308-13. |