| Description | 1,3,5,8-Tetrahydroxyxanthone (Desmethylbellidifolin) is a natural xanthone extracted from Gentianella acuta. 1,3,5,8-Tetrahydroxyxanthone has antispasmodic effect and anti-inflammatory activity. Dimethylbellidifolin shows mutagenicity in Salmonella typhimurium TA100, TA98, TA97, and TA2637 by the preincubation method; it also exhibits at the dose of 200 ug/disk a significant inhibition of the growth of Staphylococcus aureus. |
| In vitro | 自然发生的黄酮类化合物在Salmonella typhimurium TA100、TA98、TA97和TA2637中的致突变性通过预孵育法进行了测试。Xanthydrol、gentisein、gentisin、isogentisin、1-hydroxy-3,7-dimethoxyxanthone、1,3,7-trimethoxyxanthone、Desmethylbellidifolin、bellidifolin和dimethylbellidifolin显示出致突变性，而未取代的xanthone对TA100、TA98、TA97和TA2637无论是否有代谢激活系统皆不显示致突变性[1]。 |
| Synonyms | Desmethylbellidifolin, 去甲基雏叶龙胆酮 |
| molecular weight | 260.2 |
| Molecular formula | C13H8O6 |
| CAS | 2980-32-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 10 mg/mL (38.43 mM) |
| References | 1. Mutagenicities of xanthone derivatives in Salmonella typhimurium TA100, TA98, TA97, and TA2637.Mutat Res. 1985 Jun-Jul;150(1-2):141-6. |