| Description | Aspoxicillin, a broad-spectrum antimicrobial agent, demonstrates efficacy against 68 isolates of Actinobacillus pleuropneumoniae, with a minimum inhibitory concentration (MIC90) of <= 0.05 μg/ml. It exhibits a prolonged half-life of 55 minutes in mouse serum. |
| In vitro | Aspoxicillin 在体外抑制金黄色葡萄球菌Smith 生长[2]。 |
| In vivo | Aspoxicillin在小鼠血清中的半衰期长达55分钟。在中性粒细胞减少的小鼠大腿感染模型中，Aspoxicillin对金黄色葡萄球菌（Staphylococcus aureus）Smith株诱导的体内持续抗菌效应（PAEs）为5.2小时[2]。 |
| molecular weight | 493.53 |
| Molecular formula | C21H27N5O7S |
| CAS | 63358-49-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: 20 mg/mL (40.52 mM), Sonication is recommended. |
| References | 1. Yoshimura H, et al. Comparative in vitro activity of 16 antimicrobial agents against Actinobacillus pleuropneumoniae. Vet Res Commun. 2002 Jan;26(1):11-9. 2. Oshida T, et al. Activity of sub-minimal inhibitory concentrations of aspoxicillin in prolonging the postantibiotic effect against Staphylococcus aureus. J Antimicrob Chemother. 1990 Jul;26(1):29-38. |