| Description | Inauhzin (INZ)(INZ) is a novel small molecule that effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human Y cells without causing apparently genotoxic stress(IC50=3 uM, in A549 cell). |
| Target activity | SIRT1:3 μM |
| Synonyms | INZ |
| molecular weight | 469.58 |
| Molecular formula | C25H19N5OS2 |
| CAS | 309271-94-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 45 mg/mL (95.83 mM) |
| References | 1. Zhang Q, et al. EMBO Mol Med. 2012 Apr; 4(4): 298-31 |
| Citations | 1. Sun Y, Yang Y M, Hu Y Y, et al. Inhibition of nuclear deacetylase Sirtuin-1 induces mitochondrial acetylation and calcium overload leading to cell death. Redox Biology. 2022: 102334 2. Sun Y, Yang Y M, Hu Y Y, et al. Inhibition of nuclear deacetylase Sirtuin-1 induces mitochondrial acetylation and calcium overload leading to cell death. Redox Biology. 2022: 102334 |