| Description | SRT 1460 is a SIRT1 activator. |
| In vitro | SRT1460 inhibited cell growth and survival of pancreatic cancer cells[1]. |
| Cell experiments | Patu8988t (pancreatic cancer cells), Panc-1 (pancreatic cancer cells), SU86.86 (pancreatic cancer cells), HPDE cells.?Concentration:2 μM, 4 μM, 6 μM.?Incubation Time:72 hours[1] |
| Target activity | SIRT1:2.9 μM (EC1.5) |
| Synonyms | 3,4,5-三甲氧基-N-(2-(3-(哌嗪-1-基甲基)咪唑并[2,1-B]噻唑-6-基)苯基)苯甲酰胺, SRT1460 |
| molecular weight | 507.6 |
| Molecular formula | C26H29N5O4S |
| CAS | 925432-73-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 5.08 mg/mL (10 mM), Sonication is recommended. |
| References | 1. Chini CC, Espindola-Netto JM, Mondal G,et al. SIRT1-Activating Compounds (STAC) Negatively Regulate Pancreatic Cancer Cell Growth and Viability Through a SIRT1 Lysosomal-Dependent Pathway[J]. clinical cancer research, 2016, 22(10):2496-2507. 2. SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1.J Biol Chem. 2010 Mar 12;285(11):8340-51.Pacholec M, Bleasdale JE, Chrunyk B,et al. |