| Description | SIRT5 inhibitor 1 is a potent and selective inhibitor of human Sirtuin 5 deacylase (IC50: 0.11 μM). sIRT5 inhibitor 1 is associated with ageing-related diseases. |
| In vitro | SIRT5 inhibitor 1 is a very potent inhibitor of human sirtuin 5 deacylase(IC50 of 0.11 μM, >100-fold from compound.[1] |
| Target activity | Sirtuin:0.11 μM , Sirtuin:0.11 μM |
| molecular weight | 674.81 |
| Molecular formula | C31H39FN6O6S2 |
| CAS | 2166487-21-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 112.5 mg/mL (166.7 mM ), Sonication is recommended. |
| References | 1. Rajabi N, et al. Mechanism-Based Inhibitors of the Human Sirtuin 5 Deacylase: Structure-Activity Relationship, Biostructural, and Kinetic Insight. Angew Chem Int Ed Engl. 2017 ; 56(47):14836-14841. 2. Molinari F, et al. SIRT5 Inhibition Induces Brown Fat-Like Phenotype in 3T3-L1 Preadipocytes. Cells. 2021 ; 10(5):1126. |