| Description | Hoechst 34580 xHCl(23555-00-2(free base) is a cell-permeable fluorescent dye, is used for staining DNA and nuclei. |
| In vitro | Hoechst 34580 是一种治疗阿尔茨海默病的良好候选物，通过抑制 Aβ 的形成发挥作用。在 37°C 下，与 50 μM Aβ42 溶液共孵育 70 h 的 Hoechst 34580 浓度分别为 100、25、12.5、3.125、0.78、0.1 及 0.01 μM。结果显示，Hoechst 34580 能够以剂量依赖的方式抑制 Aβ42 的聚集。通过测定 Hoechst 34580 的浓度以维持 Aβ42 浓度得到的 IC50 值为 0.86±0.05 μM。 |
| Synonyms | HOE 34580 xHCl |
| molecular weight | N/A |
| Molecular formula | C27H29N7.xHCl |
| Storage | keep away from direct sunlight|Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 11 mg/ml, Sonication is recommended. |
| References | 1. Thai NQ, et al. Discovery of DNA dyes Hoechst 34580 and 33342 as good candidates for inhibiting amyloid beta formation: in silico and in vitro study. J Comput Aided Mol Des. 2016 Aug;30(8):639-50. |