| Description | MK-0752, a γ-secretase inhibitor, reduces Aβ40 production(IC50=5 nM). |
| In vitro | 在豚鼠体内,口服 MK-0752（10 -30 mg/kg）,在血浆,大脑和脑脊液中Aβ40以剂量依赖性减少.在猕猴中, MK-0752（240 mg/kg）能够减少大脑中Aβ生成的生成. |
| In vivo | 在人SH-SY5Y细胞中（IC50=5 nM）,MK-0752能够以剂量依赖性减少Aβ40。 |
| Target activity | β-Amyloid:5 nM |
| molecular weight | 442.9 |
| Molecular formula | C21H21ClF2O4S |
| CAS | 471905-41-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: < 1 mg/mL (insoluble or slightly soluble) DMSO: 89 mg/mL (200.94 mM) Ethanol: 45 mg/mL (101.6 mM) |
| References | 1. Cook JJ, et al. J Neurosci, 2010, 30(19), 6743-6750. 2. Harrison H, et al. Cancer Res, 2010, 70(2), 709-718. |