| Description | Geniposide is an iridoid glycoside with a variety of biological activities including neuroprotective, anti-diabetic, antiproliferative, and antioxidative activity. Geniposide has been shown to regulate Nrf2 translocation. |
| In vitro | Geniposide在多种生理活动中展现效果，包括抗血栓、抗炎、抗糖尿病、抗动脉粥样硬化、抗抑郁、改善阿尔茨海默病（AD）、降低高血压、毒理学性质及不良反应等[1]。在OGD诱导的脑微血管内皮细胞中，Geniposide显著降低了IL-8、IL-1β和MCP-1的产生，显著下调P2Y14受体的表达，并抑制RAF-1、MEK1/2、ERK1/2的磷酸化[2]。 |
| In vivo | Geniposide（200及400 mg/kg）以剂量依赖性显著降低糖尿病小鼠的血糖、胰岛素和TG水平。该化合物还在mRNA及免疫活性蛋白水平和酶活性上降低GP与G6Pase的表达[3]。Geniposide（20.0、40.0或80 mg/kg）显著逆转因过量饮酒引起的血清ALT/AST和肝脏LPO水平的异常升高。Geniposide通过上调血红素加氧酶-1（HO-1）的表达，减轻3-吗啉基肼氯化物（SIN-1）在原代培养的海马神经元中诱导的细胞凋亡[4]。Geniposide抑制体内光化学诱导的血栓形成模型。Geniposide通过干扰IκB降解极为有效地抑制NF-κB[1]。 |
| Cell experiments | The third passages of brain microvascular endothelial cells (BMECs) are used for the experiment. The BMECs are divided into four groups: (1)normal control group: the normal cultured BMECs without treatment; (2)OGD group: the BMECs injured by OGD according to the above method; (3) geniposide group: the OGD-injured BMECs treated with 33.2 μg/mL geniposide for 6 h; (4)PTX group: the OGD-injured BMECs administrated with 100 ng/mL PTX. PTX, known as an inhibitor of Gi-coupled receptor is used to assess the activation of P2Y14 receptor induced by OGD in this experiment[2]. |
| Synonyms | 栀子苷, 京尼平甙 |
| molecular weight | 388.37 |
| Molecular formula | C17H24O10 |
| CAS | 24512-63-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 50 mg/mL (128.74 mM) |
| References | 1. Liu H, et al. Fructus Gardenia (Gardenia jasminoides J. Ellis) phytochemistry, pharmacology ofcardiovascular, and safety with the perspective of new drugs development. J Asian Nat Prod Res. 2013;15(1):94-110. 2. Li F, et al. Geniposide attenuates inflammatory response by suppressing P2Y14 receptor and downstream ERK1/2 signaling pathway in oxygen and glucose deprivation-induced brain microvascular endothelial cells. J Ethnopharmacol. 2016 Jun 5;185:77-86. 3. Wu SY, et al. Effect of geniposide, a hypoglycemic glucoside, on hepatic regulating enzymes in diabetic mice induced by a high-fat diet and streptozotocin. Acta Pharmacol Sin. 2009 Feb;30(2):202-8. 4. Wang J, et al. Geniposide protects against acute alcohol-induced liver injury in mice via up-regulating the expression of the main antioxidant enzymes. Can J Physiol Pharmacol. 2015 Apr;93(4):261-7. |