| Description | GW438014A is a potent, selective antagonist of the NPY-Y5 receptor, effectively inhibiting food consumption and curbing body weight gain in obese rodents. |
| In vivo | GW438014A（10 mg/kg；i.p.；每日，连续7天）抑制大鼠的自发性摄食、过夜禁食诱发的摄食以及NPY诱发的摄食，并抑制基因型肥胖ob/ob小鼠在食物匮乏下的摄食。[2] |
| Synonyms | GW 438014 A, GW-438014-A |
| molecular weight | 437.51 |
| Molecular formula | C23H23N3O4S |
| CAS | 469861-49-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 225.0 mg/mL (514.3 mM), Sonication is recommended. |
| References | 1. Benmaamar R, et al. Neuropeptide Y Y5 receptors inhibit kindling acquisition in rats. Regul Pept. 2005 Feb 15;125(1-3):79-83. 2. Daniels AJ, et al. Food intake inhibition and reduction in body weight gain in lean and obese rodents treated with GW438014A, a potent and selective NPY-Y5 receptor antagonist. Regul Pept. 2002;106(1-3):47-54. |